CK1 delta Active Protein | CK1d active protein

Recombinant Human CK1 delta (N-His tag)

Cat. Num. AAA4160084

• Gene Names: CSNK1D; ASPS; CKId; HCKID; FASPS2; CKIdelta; CKI-delta
• Purity: 70%-90%
• Synonyms: CK1 delta; Recombinant Human CK1 delta (N-His tag); CSNK1D; HCKID; CK1D; CK1d active protein

• Host: Insect Cells
• Purity/Purification: 70%-90%
• Form/Format: Liquid; 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Sequence Length: 3681

• Bioactivity: The specific activity of CK1d was determined to be 82 nmol/min/mg as per activity assay protocol.
• Preparation and Storage: Store product at-70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.; For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Related Product Information for CK1d active protein

CK1d is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK1d is a regulator of Yes-associated protein (YAP) transcription coactivator which is a key regulator of organ size and a candidate human oncogene. CK1d is activated by CCK2R and this then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CKId can phosphorylate in vitro deoxycytidine kinase (dCK) which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKId in vitro correlates with increased activity of this enzyme.

NCBI and Uniprot Product Information

• NCBI GI #: 1677500573
• NCBI GeneID: 1453
• NCBI Accession #: NM_001893.6
• NCBI GenBank Nucleotide #: NM_001893
• UniProt Accession #: P48730
• Molecular Weight: 72.0 kDa
• NCBI Official Full Name: Homo sapiens casein kinase 1 delta (CSNK1D), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: casein kinase 1 delta
• NCBI Official Symbol: CSNK1D
• NCBI Official Synonym Symbols: ASPS; CKId; HCKID; FASPS2; CKIdelta; CKI-delta
• NCBI Protein Information: casein kinase I isoform delta; casein kinase I
• UniProt Protein Name: Casein kinase I isoform delta
• UniProt Gene Name: CSNK1D
• UniProt Synonym Gene Names: HCKID; CKI-delta; CKId
• UniProt Entry Name: KC1D_HUMAN

NCBI Description

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Description

CK1D: an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described.

Protein type: EC 2.7.11.26; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: Golgi apparatus; centrosome; spindle microtubule; perinuclear region of cytoplasm; plasma membrane; spindle; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; phosphoprotein binding; glycoprotein binding; peptide binding; ATP binding; protein kinase activity

Biological Process: Wnt receptor signaling pathway; organelle organization and biogenesis; endocytosis; spindle assembly; signal transduction; regulation of circadian rhythm; DNA repair; protein amino acid phosphorylation; regulation of cell shape; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; circadian regulation of gene expression; G2/M transition of mitotic cell cycle

Disease: Advanced Sleep Phase Syndrome, Familial, 2