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DDR1 active protein

Recombinant Human DDR1 (N-GST tag)

Gene Names
DDR1; CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
Purity
70%-90%
Synonyms
DDR1; Recombinant Human DDR1 (N-GST tag); CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; DDR1 active protein
Ordering
For Research Use Only!
Host
Insect Cells
Purity/Purification
70%-90%
Form/Format
Liquid; 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Sequence Length
876
Bioactivity
The specific activity of DDR1 was determined to be 5 nmol/min/mg as per activity assay protocol.
Preparation and Storage
Store product at-70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Related Product Information for DDR1 active protein
DDR1 is a member of the subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in its extracellular domain. DDR1 is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. Expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain and DDR1 is over-expressed in fast-growing invasive tumors of the breast, ovary, esophagus, brain and lung. Collagen type I mediated stimulation of DDR1 leads to activation of matrix metalloproteinase 2 and 9 as well as increased cell invasion.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
780
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
77.0 kDa
NCBI Official Full Name
DDR1
NCBI Official Synonym Full Names
discoidin domain receptor tyrosine kinase 1
NCBI Official Symbol
DDR1
NCBI Official Synonym Symbols
CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
NCBI Protein Information
epithelial discoidin domain-containing receptor 1

NCBI Description

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Research Articles on DDR1

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Product Notes

The DDR1 (Catalog #AAA4160103) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DDR1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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