CLK2 active protein

Recombinant Human CLK2 (N-GST tag)

Cat. Num. AAA4160092

• Purity: 70%-90%
• Synonyms: CLK2; Recombinant Human CLK2 (N-GST tag); hCLK2; MGC61500; CLK2 active protein

• Host: Insect Cells
• Purity/Purification: 70%-90%
• Form/Format: Liquid; 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Sequence Length: 499

• Bioactivity: The specific activity of CLK2 was determined to be 52 nmol/min/mg as per activity assay protocol.
• Preparation and Storage: Store product at-70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.; For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Related Product Information for CLK2 active protein

CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.

NCBI and Uniprot Product Information

• NCBI GI #: 632968
• NCBI GeneID: 1196
• NCBI GenBank Nucleotide #: NM_003993
• Molecular Weight: 68.0 kDa
• NCBI Official Full Name: clk2; putative
• NCBI Official Synonym Full Names: CDC like kinase 2
• NCBI Official Symbol: CLK2
• NCBI Protein Information: dual specificity protein kinase CLK2
• Protein Family: Dual specificity protein kinase

NCBI Description

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]