Phosphatidylinositide phosphatase SAC2 (Inpp5f) Recombinant Protein | Inpp5f recombinant protein

Recombinant Mouse Phosphatidylinositide phosphatase SAC2 (Inpp5f) , partial

• Gene Names: Inpp5f; SAC2; cI-27; hSAC2; AI115354; AW561896; mKIAA0966; 5830435P03Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phosphatidylinositide phosphatase SAC2 (Inpp5f); Recombinant Mouse Phosphatidylinositide phosphatase SAC2 (Inpp5f); partial; Inpp5f recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 505

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Inpp5f recombinant protein

This protein is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants have been observed, but most of them are not thought to be protein-coding.

NCBI and Uniprot Product Information

• NCBI GI #: 1081677988
• NCBI GeneID: 101490
• NCBI Accession #: NP_001333446.1
• NCBI GenBank Nucleotide #: NM_001346517.1
• UniProt Accession #: Q8CDA1; Q3UCS0; Q6NX83; Q6ZQ16; Q8C8G7; Q8CBW2
• Molecular Weight: 48,995 Da
• NCBI Official Full Name: phosphatidylinositide phosphatase SAC2 isoform 2
• NCBI Official Synonym Full Names: inositol polyphosphate-5-phosphatase F
• NCBI Official Symbol: Inpp5f
• NCBI Official Synonym Symbols: SAC2; cI-27; hSAC2; AI115354; AW561896; mKIAA0966; 5830435P03Rik
• NCBI Protein Information: phosphatidylinositide phosphatase SAC2
• UniProt Protein Name: Phosphatidylinositide phosphatase SAC2
• Protein Family: Phosphatidylinositide phosphatase
• UniProt Gene Name: Inpp5f
• UniProt Synonym Gene Names: hSAC2

Uniprot Description

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726). May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138).