Human inositol polyphosphate-5-phosphatase, 75kDa ELISA Kit | INPP5B elisa kit
Human Type II inositol-1, 4, 5-trisphosphate 5-phosphatase, INPP5B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Uniprot Description
INPP5B: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein); Motility/polarity/chemotaxis; EC 3.1.3.36
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: Golgi apparatus; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; ER-Golgi intermediate compartment; plasma membrane; integral to membrane; cytosol
Molecular Function: protein binding; metal ion binding; phosphoinositide 5-phosphatase activity
Biological Process: sperm motility; regulation of small GTPase mediated signal transduction; inositol phosphate metabolic process; in utero embryonic development; small GTPase mediated signal transduction; phosphoinositide dephosphorylation; spermatogenesis
Research Articles on INPP5B
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Product Notes
The Human INPP5B inpp5b (Catalog #AAA9342949) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342949 ELISA Kit recognizes Human INPP5B. It is sometimes possible for the material contained within the vial of "inositol polyphosphate-5-phosphatase, 75kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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