Chemical Structure
YM155 (Sepantronium Bromide), Inhibitor
YM155 (Sepantronium Bromide)
Purity
>98%
Synonyms
YM155 (Sepantronium Bromide); inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 22.56 mL (1 mg); 112.79 mL (5 mg); 225.58mL (10 mg)
0.5 mM: 4.51 mL (1 mg); 22.56 mL (5 mg); 45.12 mL (10 mg)
1 mM: 2.26 mL (1 mg); 11.28 mL (5 mg); 22.56 mL (10 mg)
5 mM: 0.45 mL (1 mg); 2.26 mL (5 mg); 4.51 mL (10 mg) (varies by lot)
0.5 mM: 4.51 mL (1 mg); 22.56 mL (5 mg); 45.12 mL (10 mg)
1 mM: 2.26 mL (1 mg); 11.28 mL (5 mg); 22.56 mL (10 mg)
5 mM: 0.45 mL (1 mg); 2.26 mL (5 mg); 4.51 mL (10 mg) (varies by lot)
CAS Number
781661-94-7
Formula
C20H19BrN4O3
SMILES
CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
Actions
Inhibitor
In Vivo Solvent
Saline
Solubility (DMSO)
55 mg/mL (124.07 mM)
Solubility (Ethanol)
6 mg/mL (13.53 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
89 mg/mL (200.77 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for YM155 (Sepantronium Bromide), inhibitor
YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
References
Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
Yamamoto M, .et al. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1, Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
V??zquez-Mellado MJ, .et al. Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells, Oncol Rep, 2018, Nov 27 PMID: 30483799
MASAHIRO YAMAMOTO, .et al. AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel, Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
Ahn MR, .et al. Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway, Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
MASAYA MINODA, .et al. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS, Int J Oncol., 2015, Sep; 47(3): 891-899 PMID: 26166250
Yamamoto M, .et al. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1, Anticancer Res, 2019, Feb;39(2):609-617 PMID: 30711936
V??zquez-Mellado MJ, .et al. Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells, Oncol Rep, 2018, Nov 27 PMID: 30483799
MASAHIRO YAMAMOTO, .et al. AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel, Anticancer Res, 2018, Dec 38 (12) 6699-6706 PMID: 30504379
Ahn MR, .et al. Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway, Drug Discov Ther, 2017, 11(6):300-306 PMID: 29332887
MASAYA MINODA, .et al. Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS, Int J Oncol., 2015, Sep; 47(3): 891-899 PMID: 26166250
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Product Notes
The YM155 (Sepantronium Bromide) (Catalog #AAA385767) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "YM155 (Sepantronium Bromide), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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