Tartrazine, Inhibitor

Tartrazine

Cat. Num. AAA5760966

• Purity: 98.00%
• Synonyms: Tartrazine; Acid Yellow 23; FD&C Yellow No. 5; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 10mg/mL (18.71mM); Need ultrasonic and warming; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C16H9N4Na3O9S2
• SMILES: C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)[O-])C(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+]
• CAS Number: 1934-21-0
• Target & IC50: Others
• In Vitro: We assessed the cytotoxicity of Tartrazine by 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide test and the response of DNA repair through comet assay (alkaline version). We used different concentrations of the dye, ranging from 0.25-64.0mM. The results demonstrated that Tartrazine has no cytotoxic effects. However, this dye had a significant genotoxic effect at all concentrations tested. Although most of the damage was amenable to repair, some damage remained higher than positive control after 24 hours of repair[1]
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Related Product Information for Tartrazine, inhibitor

Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo group; it has significant genotoxic effect, may be harmful to health and its prolonged use could trigger carcinogenesis.

References

Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Anticancer Res. 2015 Mar;35(3):1465-74.
Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Anticancer Res. 2015 Mar;35(3):1465-74.
Assessment of the breakdown products of solar/UV induced photolytic degradation of food dye tartrazine.Food Chem Toxicol. 2014 Jun;68:307-15.