Structure
Spastazoline, Inhibitor
Spastazoline
Purity
100.00%
Synonyms
Spastazoline; inhibitor
Purity/Purification
100.00%
Form/Format
Solid. Powder
Solubility
DMSO: 95mg/mL (248.36mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H30N8
SMILES
CC(C)[C@@H]1CN(CCN1)c1nc(Nc2cc([nH]n2)C(C)(C)C)c2cc[nH]c2n1
CAS Number
2351882-11-4
Target & IC50
Human spastin: ic50 99nM
spastin: ic50 99nM
spastin: ic50 99nM
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Spastazoline, inhibitor
Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99nM).
References
Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb
Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb
Pisa R, Cupido T, Steinman J B, et al. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins[J].
Pisa R, Cupido T, Steinman J B, et al. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins[J].
Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb
Pisa R, Cupido T, Steinman J B, et al. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins[J].
Pisa R, Cupido T, Steinman J B, et al. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins[J].
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Product Notes
The Spastazoline (Catalog #AAA5759305) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Spastazoline, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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