SCH00013, inhibitor
SCH00013
Purity
98.00%
Synonyms
SCH00013; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C18H20N4O2
SMILES
N#CC1=CC=C(C(O)CN2CC=C(C(CC3)=NNC3=O)CC2)C=C1
CAS Number
217963-18-3
Target & IC50
Others
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Related Product Information for SCH00013, inhibitor
SCH00013 is an agent of cardiotonic that primarily acts via an increase in myofibrillar Ca++ sensitivity. SCH00013 have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.
References
Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60.
Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60.
Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66.
Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66.
Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60.
Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60.
Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66.
Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66.
