Chemical Structure
RSL3, inhibitor
RSL3
Purity
>98%
Synonyms
RSL3; 1S; 3R-RSL3; inhibitor
Purity/Purification
>98%
Solubility
DMSO
Formula
C23H21ClN2O5
SMILES
COC (C1=CC=C ([C@@]2 ([H])C3=C (C4=CC=CC=C4N3)C[C@] (N2C (CCl)=O) ([H])C (OC)=O)C=C1)=O
CAS Number
1219810-16-8
Preparation and Storage
Store at -20 degree C for 3 years (powder form); at -20 degree C for 6 months (Solution base)
Chemical Structure
Chemical Structure
Related Product Information for RSL3, inhibitor
RSL3 is a ferroptosis activator in a VDAC-independent manner, exhibiting selectivity for tumor cells bearing oncogenic RAS.
Product Categories/Family for RSL3, inhibitor
References
Sampilvanjil A,.et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318 (3):H508-H518 PMID: 31975626
Fujiki K,.et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
Samantha W. Alvarez,.et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551 (7682): 639-643 PMID: 29168506
Fujiki K,.et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
Samantha W. Alvarez,.et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551 (7682): 639-643 PMID: 29168506
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Product Notes
The RSL3 (Catalog #AAA3841226) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RSL3, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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