Structure
Rpn13 degrader WL40, Inhibitor
Rpn13 degrader WL40
Purity
>98% (HPLC)
Synonyms
Rpn13 degrader WL40; WL40; inhibitor
Purity/Purification
>98% (HPLC)
Target
PROTAC
Receptor
PROTAC
Chemical Name
N-((S)-1-(3, 5-bis((Z)-3, 4-dichlorobenzylidene)-4-oxopiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-3-(2-(2-(2-((2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanamide
Molecular Formula
C50H47Cl4N5O10
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Rpn13 degrader WL40, inhibitor
Rpn13 degrader WL40 (WL40) is a novel covalent ubiquitin receptor Rpn13 degrader by linking the Rpn13 covalent inhibitor RA190 with the cereblon (CRBN) binding ligand thalidomide; binds to both Rpn13 and CRBN and triggers degradation of cellular Rpn13; WL40 decreases viability in MM cell lines and patient MM cells (IC50=400-750nM), even those resistant to bortezomib, WL40 interrupts Rpn13 function and activates caspase apoptotic cascade, ER stress response and p53/p21 signaling; inhibits xenografted human MM cell growth and prolongs survival in animal model studies.
Product Categories/Family for Rpn13 degrader WL40, inhibitor
References
1. Song Y, et al. Leukemia. 2019 Apr 8. doi: 10.1038/s41375-019-0467-z.
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Product Notes
The Rpn13 degrader WL40 (Catalog #AAA3606949) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rpn13 degrader WL40, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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