Rose Bengal, Inhibitor
Rose Bengal
Purity
98.00%
Synonyms
Rose Bengal; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C20H2Cl4I4Na2O5
SMILES
O=C1OC2(c3cc(I)c([O-])c(I)c3Oc3c2cc(I)c([O-])c3I)c2c(Cl)c(Cl)c(Cl)c(Cl)c21.[Na+].[Na+]
CAS Number
632-69-9
Target & IC50
vesicular monoamine transporter (VMAT)
Cell Research
Bacteria were grown to a concentration of 10^8 CFU/mL and then diluted with sterile saline by serial decimal dilutions to concentrations of 10^3-10^7 CFU/mL. Three milliliters of bacterial suspensions was transferred into flat-bottom 2.5cm diameter 20mL vials. Before the experiment, samples were taken from each vial to determine the initial bacterial concentration. Free Rose Bengal at various concentrations or Rose Bengal immobilized onto silicone was added to all vials, except for the controls. After adding Rose Bengal, all subsequent procedures were performed under dark conditions. Vials with bacterial suspensions with or without Rose Bengal were held tight to the bottom of an ultrasonic bath in a plastic holder VU03H and treated by ultrasound at a frequency of 38 kHz and a field strength of 4.1 W/cm^3 for 1 to 10 minutes. After the treatment, 100uL samples were diluted by several decimal dilutions and were spread over BHA plates with a Drigalsky spreader. The plates were incubated at 37 degree C overnight and the bacterial cell concentration was determined taking dilutions into account using the viable count method, where CFU were counted by means of a colony counter Scan 500. In control experiments, bacterial cultures were tested in the absence of Rose Bengal without sonication, in the absence of Rose Bengal under sonication and in the presence of Rose Bengal without sonication[1].
In Vitro
Rose Bengal immobilized onto silicon showed good antibacterial activity in the dark under ultrasonic activation[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Rose Bengal, inhibitor
Rose Bengal is a potent inhibitor of VGlut and vesicular monoamine transporter (VMAT) (Ki of 19 and 64nM for VGlut andVMAT, respectively)
Product Categories/Family for Rose Bengal, inhibitor
References
Faina Nakonechny, Margarita Barel, Arad David,et al.Dark Antibacterial Activity of Rose Bengal[J]. Int J Mol Sci, 20 (13) 2019 Jun 29
Faina Nakonechny, Margarita Barel, Arad David,et al.Dark Antibacterial Activity of Rose Bengal[J]. Int J Mol Sci, 20 (13) 2019 Jun 29
Anju V, Paramanantham P, Sruthil S L, et al. Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli[J]. Photodiagnosis and Photodynamic Therapy, 2018.
Anju V, Paramanantham P, Sruthil S L, et al. Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli[J]. Photodiagnosis and Photodynamic Therapy, 2018.
Faina Nakonechny, Margarita Barel, Arad David,et al.Dark Antibacterial Activity of Rose Bengal[J]. Int J Mol Sci, 20 (13) 2019 Jun 29
Anju V, Paramanantham P, Sruthil S L, et al. Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli[J]. Photodiagnosis and Photodynamic Therapy, 2018.
Anju V, Paramanantham P, Sruthil S L, et al. Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli[J]. Photodiagnosis and Photodynamic Therapy, 2018.
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Product Notes
The Rose Bengal (Catalog #AAA5758543) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rose Bengal, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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