Structure
Ro 31-8220 Mesylate, Inhibitor
Ro 31-8220 Mesylate
Purity
>98% (HPLC)
Synonyms
Ro 31-8220 Mesylate; RO31-8220; RO318220; RO-318220; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=50mg/mL (90.31mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
Other Targets
Receptor
PKCalpha; PKCbeta1; PKCbeta2; PKCgamma; PKCepsilon
Chemical Name
3-(3-(4-(1-methyl-1H-indol-3-yl)-2, 5-dioxo-2, 5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate methanesulfonate
SMILES
Cn1cc(c2ccccc12)C1=C(C(=O)NC1=O)c1cn(c2ccccc12)CCCSC(=N)N.CS(=O)(=O)O
Molecular Formula
C25H23N5O2S·CH4O3S
CAS Number
138489-18-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ro 31-8220 Mesylate, inhibitor
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50=1.35 x 10 (-6) M) or diacylglycerols (OAG, diC8) by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells.
Product Categories/Family for Ro 31-8220 Mesylate, inhibitor
References
1. Wilkinson SE, et al. Biochem J. 1993, 294 (Pt 2), 335-337.
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Product Notes
The Ro 31-8220 Mesylate (Catalog #AAA3607265) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ro 31-8220 Mesylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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