RG 14620, inhibitor
RG 14620
Purity
99.6%
Synonyms
RG 14620; inhibitor
Purity/Purification
99.6%
Form/Format
POWDER
CAS
136831-49-7
Formula
C14H8Cl2N2
Pathways
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Target
HER 14 DNA synthesis
Smiles
Clc1cc(Cl)cc(\C=C(\C#N)c2cccnc2)c1
Receptor
HER14 colony formation; HER14 DNA synthesis
Bioactivity
RG14620 is an epidermal growth factor receptor (EGFR) inhibitor, with IC50 values of 3 muM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis.
Solubility
DMSO: >= 26 mg/mL
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
For 2 years -80 degree C in solvent.
Product Categories/Family for RG 14620, inhibitor
References
1. Yoneda T,et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15; 51 (16):4430-5.
Similar Products
Product Notes
The RG 14620 (Catalog #AAA579671) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RG 14620, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
