Structure
RCM-1, inhibitor
RCM-1
Purity
98.00%
Synonyms
RCM-1; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 16.67mg/mL (39.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H12N2OS4
SMILES
O=C(CSc1nc(cc(-c2cccs2)c1C#N)-c1cccs1)c1cccs1
CAS Number
339163-65-4
Target & IC50
FOXM1
In Vitro
RCM-1 decreases the B 16-FlO tumor growth as compared to the Vehicle -treated group. RCM-1 treatment,decreases tumor cell proliferation and increased apoptosis in B16-FlO melanoma tumors. RCM-1 treatment,reduces the growth of the human H2122 lung adenocarcinoma in mice. RCM-1 treatment,reduces tumor cell proliferation and increases apoptosis in Rd76-9 rhabdomyosarcoma tumors. RCM-1 treatment,decreases the growth of Rd76-9 rhabdomyosarcomas in mice. The RCM-1-treated Rd76-9 tumors display reduced FOXM1 staining and decreased expression of proliferation-specific markers Ki67 and PH3. Cleaved caspase staining is increased in the RCM-1 treated tumors, indicating an increase in apoptosis. RCM-1 treatment,reduces the growth of B16-FlO melanoma tumors in mice [1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for RCM-1, inhibitor
RCM-1 is an inhibitor of FOXM1.
References
ARYL SULFONOHYDRAZIDES.WO2018057550A1.
ARYL SULFONOHYDRAZIDES.WO2018057550A1.
ARYL SULFONOHYDRAZIDES.WO2018057550A1.
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Product Notes
The RCM-1 (Catalog #AAA5755443) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RCM-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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