Protein Kinase Inhibitor Peptide, Inhibitor | PEBP1, inhibitor

Protein Kinase Inhibitor Peptide (PKI)

Cat. Num. AAA655477

• Gene Names: PEBP1; PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1
• Purity: Highly Purified; ~90% by HPLC and MS analysis
• Synonyms: Protein Kinase Inhibitor Peptide; Protein Kinase Inhibitor Peptide (PKI); PEBP1; inhibitor

• Purity/Purification: Highly Purified; ~90% by HPLC and MS analysis
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Ile-Ala-Ala-Gly-Arg-Thr-Gly-Arg-Arg-Gln-Ala-Ile-His-Asp-Ile-Leu-Val-Ala-Ala-OH
• Amino Acid Analysis: Confirms expected sequence
• Solubility: H2O
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for PEBP1, inhibitor

Specific cAMP-dependent protein kinase inhibitor

Product Categories/Family for PEBP1, inhibitor

Molecular Biology; MB-Protein Kinase Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 1352726
• NCBI GeneID: 5037
• UniProt Accession #: P30086; B2R4S1
• Molecular Weight: 1989
• NCBI Official Full Name: Phosphatidylethanolamine-binding protein 1
• NCBI Official Synonym Full Names: phosphatidylethanolamine binding protein 1
• NCBI Official Symbol: PEBP1
• NCBI Official Synonym Symbols: PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1
• NCBI Protein Information: phosphatidylethanolamine-binding protein 1; neuropolypeptide h3; prostatic binding protein; prostatic-binding protein; raf kinase inhibitor protein; Raf kinase inhibitory protein; hippocampal cholinergic neurostimulating peptide
• UniProt Protein Name: Phosphatidylethanolamine-binding protein 1
• Protein Family: Phosphatidylethanolamine-binding protein
• UniProt Gene Name: PEBP1
• UniProt Synonym Gene Names: PBP; PEBP; PEBP-1; RKIP; HCNP
• UniProt Entry Name: PEBP1_HUMAN

NCBI Description

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

Uniprot Description

Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase

By similarity. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Ref.13HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor

By similarity. Ref.13

Subunit structure: Has a tendency to form dimers by disulfide cross-linking

By similarity. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade. Ref.11 Ref.13 Ref.18

Subcellular location: Cytoplasm

By similarity.

Sequence similarities: Belongs to the phosphatidylethanolamine-binding protein family.