Structure
PJ-68, Inhibitor
PJ-68
Purity
>98% (HPLC)
Synonyms
PJ-68; PJ68; inhibitor
Purity/Purification
>98% (HPLC)
Target
HMTase
Receptor
HMTase
Chemical Name
N-((9-ethyl-9H-carbazol-3-yl)methyl)-1, 2, 3, 4-tetrahydronaphthalen-1-amine
Molecular Formula
C25H26N2
CAS Number
352544-59-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PJ-68, inhibitor
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.
Product Categories/Family for PJ-68, inhibitor
References
1. Jin Y, et al. J Clin Invest. 2016 Oct 3; 126 (10):3961-3980.
2. Kaushik S, et al. Leukemia. 2018 Feb; 32 (2):499-509.
2. Kaushik S, et al. Leukemia. 2018 Feb; 32 (2):499-509.
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Product Notes
The PJ-68 (Catalog #AAA3604201) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PJ-68, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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