Phenylephrine, Inhibitor

Phenylephrine

Cat. Num. AAA5764705

• Purity: 0.9992
• Synonyms: Phenylephrine; (R)-(-)-Phenylephrine; L-Phenylephrine; inhibitor

• Purity/Purification: 0.9992
• Form/Format: Solid

• Solubility: H2O: 50mg/mL (245.50mM); Need ultrasonic; DMSO: 150mg/mL (736.49mM); (<1mg/ml refers to the product slightly soluble or insoluble)
• SMILES: O[C@H](C1=CC(O)=CC=C1)CNC
• Formula: C9H13NO2
• Target & IC50: Others
• In vitro: Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
• CAS Number: 59-42-7
• Preparation and Storage: Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).

Chemical Structure

Related Product Information for Phenylephrine, inhibitor

Phenylephrine is a selective alpha1-adrenoceptor agonist (pKi: 5.86,4.87 and 4.70 for alpha1D, alpha1B, and alpha1A receptors respectively).

Product Categories/Family for Phenylephrine, inhibitor

GPCR/G Protein; Neuroscience; Adrenergic Receptor

References

Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.
Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.
Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.
Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 (Pt 2):459-65.
Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.
Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020.