Structure
ORY-1001 dihydrochloride, Inhibitor
ORY-1001 dihydrochloride
Purity
>98% (HPLC)
Synonyms
ORY-1001 dihydrochloride; Ladademstat; RG-6016; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
H2O: 57.75mg/mL (190.42mM)
DMSO: 0.69mg/mL (2.28mM)
DMSO: 0.69mg/mL (2.28mM)
Target
Histone Demethylase
Receptor
Histone Demethylase
Chemical Name
(1r, 4R)-N1-((1R, 2S)-2-phenylcyclopropyl)cyclohexane-1, 4-diamine dihydrochloride
SMILES
N[C@@H]1CC[C@@H](N[C@H]2[C@H](C3=CC=CC=C3)C2)CC1.[H]Cl.[H]Cl
Molecular Formula
C15H24Cl2N2
CAS Number
1431303-72-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ORY-1001 dihydrochloride, inhibitor
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases; exhibits low nanomolar cellular activity (EC50 <1nM) in the THP1 differentiation assay and induces the CD11b marker within 6 hr of treatment in FACS based differentiation assay in THP1 cell line; induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML; exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of AML xenograft models. Blood Cancer Phase 2 Clinical
Product Categories/Family for ORY-1001 dihydrochloride, inhibitor
References
1. Maes T, et al. Cancer Cell. 2018 Mar 12; 33 (3):495-511.e12.
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Product Notes
The ORY-1001 dihydrochloride (Catalog #AAA3601825) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ORY-1001 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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