Structure
NK150460, Inhibitor
NK150460
Purity
>98% (HPLC)
Synonyms
NK150460; NK 150460; NK-150460; inhibitor
Purity/Purification
>98% (HPLC)
Target
AhR
Receptor
AhR
Chemical Name
(5S, 7S)-7-methyl-3-(3-(trifluoromethyl)phenyl)-5, 6, 7, 8-tetrahydrocinnolin-5-ol
Molecular Formula
C16H15F3N2O
CAS Number
709640-62-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NK150460, inhibitor
A potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits growth of not only most ER-positive, but also some ER-negative breast cancer cell lines, while never inhibiting growth of non-breast cancer cell lines; inhibits 17beta-estradiol (E2)-dependent transcription without affecting binding of E2 to ER; does not induce histone H2AX phosphorylation or p53 expression, is a a novel AhR agonist dependent on AhR/ARNT and cytochrome P450 CYP1A1.
Product Categories/Family for NK150460, inhibitor
References
1. Fukasawa K, et al. Mol Cancer Ther. 2015 Feb; 14 (2):343-54.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
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Product Notes
The NK150460 (Catalog #AAA3605720) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NK150460, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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