Structure
Navarixin, Inhibitor
Navarixin
Purity
98.00%
Synonyms
Navarixin; SCH 527123; MK-7123; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C21H23N3O5
CAS
473727-83-2
Smiles
CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1
Receptor (IC50)
CXCR1, CXCR2
Solubility
DMSO: 50mg/mL (125.81mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Navarixin, inhibitor
Navarixin (SCH527123) is a novel, selective CXC chemokine receptor 2 (CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
References
1. Gonsiorek W, Fan X, Hesk D, et al. Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 322 (2):477-485.
2. Holz O, Khalilieh S, Ludwig-Sengpiel A,et al.SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects[J].Eur Respir J. 2010 Mar;35 (3):564-70.
2. Holz O, Khalilieh S, Ludwig-Sengpiel A,et al.SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects[J].Eur Respir J. 2010 Mar;35 (3):564-70.
Similar Products
Product Notes
The Navarixin (Catalog #AAA5752347) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Navarixin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
