Structure
MPI-0479605, Inhibitor
MPI-0479605
Purity
>98% (HPLC)
Synonyms
MPI-0479605; MPI0479605; MPI 0479605; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 11mg/mL (26.99mM)
Target
CaMK
Receptor
Mps1
Chemical Name
N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2, 6-diamine
SMILES
n1c(nc(c2c1[nH]cn2)NC1CCCCC1)Nc1c(cc(cc1)N1CCOCC1)C
Molecular Formula
C22H29N7O
CAS Number
1246529-32-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MPI-0479605, inhibitor
MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.
Product Categories/Family for MPI-0479605, inhibitor
References
1.Tardif K D. et al. Molecular Y therapeutics, 2011, 10 (12): 2267-2275.
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Product Notes
The MPI-0479605 (Catalog #AAA3607210) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MPI-0479605, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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