Structure
ML197, Inhibitor
ML197
Purity
>98% (HPLC)
Synonyms
ML197; NCGC00185963; ML 197; inhibitor
Purity/Purification
>98% (HPLC)
Target
CLK
Receptor
CLK
Chemical Name
6-(benzo[d][1, 3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine
Molecular Formula
C20H16N4O2S
CAS Number
1222891-88-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ML197, inhibitor
ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206nM for CLK1/CLK4/Dyrk1A, respectively; inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510nM, extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells.
Product Categories/Family for ML197, inhibitor
References
1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15; 21 (10):3152-8.
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov; 10 (11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov; 10 (11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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Product Notes
The ML197 (Catalog #AAA3600847) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ML197, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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