Structure
MI 219, Inhibitor
MI 219
Purity
>98% (HPLC)
Synonyms
MI 219; MI219; inhibitor
Purity/Purification
>98% (HPLC)
Target
MDM2-p53
Receptor
MDM2-p53
Chemical Name
(2'R, 3S, 4'R, 5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3, 4-dihydroxybutyl]-2'-(2, 2-dimethylpropyl)-5-fluoro-1, 2-dihydro-2-oxospiro[3H-indole-3, 3'-pyrrolidine]-5'-carboxamide
SMILES
O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2)[C@]31C(NC4=C3C=C(F)C(Cl)=C4)=O)NCC[C@H](O)CO
Molecular Formula
C27H32Cl2FN3O4
CAS Number
908027-55-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MI 219, inhibitor
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models.
Product Categories/Family for MI 219, inhibitor
References
1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11; 105 (10):3933-8.
2. Peterson LF, et al. Leukemia. 2011 May; 25 (5):761-9.
3. Feng FY, et al. Neoplasia. 2016 Apr; 18 (4):213-22.
2. Peterson LF, et al. Leukemia. 2011 May; 25 (5):761-9.
3. Feng FY, et al. Neoplasia. 2016 Apr; 18 (4):213-22.
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Product Notes
The MI 219 (Catalog #AAA3606518) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MI 219, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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