Structure
Masitinib mesylate, Inhibitor
Masitinib mesylate
Purity
98.00%
Synonyms
Masitinib mesylate; AB-1010 mesylate; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 25mg/mL (42.03mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H34N6O4S2
SMILES
CS(O)(=O)=O.CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1
CAS Number
1048007-93-7
Target & IC50
Kit: ic50 200nM
PDGFRalpha: ic50 540nM
PDGFRbeta: ic50 800nM
LynB: ic50 510nM
PDGFRalpha: ic50 540nM
PDGFRbeta: ic50 800nM
LynB: ic50 510nM
In Vitro
Masitinib (12.5mg/kg/d, p.o.) increases overall TTP (time-to-tumor progression) compared with placebo in dogs[2]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Masitinib mesylate, inhibitor
Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200nM,540/800nM,510nM for human recombinant c-Kit;PDGFRalpha/beta;LynB, respectively).
Product Categories/Family for Masitinib mesylate, inhibitor
References
Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258.
Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.
Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.
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Product Notes
The Masitinib mesylate (Catalog #AAA5759331) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Masitinib mesylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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