Chemical Structure
Mal-amido-PEG8-NHS ester, Inhibitor
Mal-amido-PEG8-NHS ester
Synonyms
Mal-amido-PEG8-NHS ester; inhibitor
Form/Format
Solid
Solubility
DMSO: 10mM
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
Formula
C30H47N3O15
Target & IC50
PEGs, Alkyl/ether
In vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
CAS Number
756525-93-6
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for Mal-amido-PEG8-NHS ester, inhibitor
Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product Categories/Family for Mal-amido-PEG8-NHS ester, inhibitor
References
An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Similar Products
Product Notes
The Mal-amido-PEG8-NHS ester (Catalog #AAA5764683) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Mal-amido-PEG8-NHS ester, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
