Structure
LY2365109 hydrochloride, Inhibitor | LY2365109, inhibitor
LY2365109 hydrochloride
Purity
98.00%
Synonyms
LY2365109 hydrochloride; LY2365109; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 31mg/mL (73.48mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H28ClNO5
SMILES
O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
CAS Number
1779796-27-8
Target & IC50
hGlyT1: ic50 15.8nM
In Vitro
LY2365109 hydrochloride increases seizure thresholds in mice[2].LY2365109 hydrochloride (0.3-30mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for LY2365109, inhibitor
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8nM for glycine uptake in cells over-expressing hGlyT1a.
References
Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
Shen HY et al. Glycine transporter 1 is a target for the treatment,of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Shen HY et al. Glycine transporter 1 is a target for the treatment,of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
Shen HY et al. Glycine transporter 1 is a target for the treatment,of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Shen HY et al. Glycine transporter 1 is a target for the treatment,of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
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Product Notes
The LY2365109 (Catalog #AAA5753440) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2365109 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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