Structure
LHF-535, Inhibitor
LHF-535
Purity
>98% (HPLC)
Synonyms
LHF-535; LHF535; LHF 535; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 96.67mg/mL (234.34mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
Arenavirus
Receptor
Arenavirus
Chemical Name
(Z)-2-(4-(2-(1-(4-isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol
SMILES
CC(O)(C1=CC=C(/C=CC2=CC=C3N(C4=CC=C(OC(C)C)C=C4)C=NC3=C2)C=C1)C
Molecular Formula
C27H28N2O2
CAS Number
1450929-77-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LHF-535, inhibitor
LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3nM; LHF-535 has sub-nanomolar potency against the viral envelope glycoproteins from all Lassa virus lineages, with the exception of the glycoprotein from the LP strain from lineage I, which was 100-fold less sensitive than that of other strains; potently inhibited Junin virus, but not Candid#1 in virus-yield reduction assays; protects mice in a lethal Tacaribe virus model at 10mg/kg. Other Indication Phase 1 Clinical
Product Categories/Family for LHF-535, inhibitor
References
1. Madu IG, et al. PLoS Pathog. 2018 Dec 21; 14 (12):e1007439.
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Product Notes
The LHF-535 (Catalog #AAA3601942) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LHF-535, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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