Structure
Indoxyl sulfate potassium salt, Inhibitor
Indoxyl sulfate potassium salt
Purity
98.00%
Synonyms
Indoxyl sulfate potassium salt; Potassium 3-indoxyl sulfate; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C8H6KNO4S
CAS
2642-37-7
Smiles
[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12
Receptor (IC50)
AhR
Solubility
DMSO: Soluble
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Indoxyl sulfate potassium salt, inhibitor
Indoxyl sulfate (potassium salt) is an agonist for the human aryl hydrocarbon receptor (AHR). The aryl hydrocarbon receptor (AhR) has recently emerged as a pathophysiological regulator of immune-inflammatory conditions and Indoxyl sulfate has been shown to be a ligand for AhR. Indoxyl sulfate is also a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, indoxyl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. Indoxyl sulfate at 250uM can induce the activation of NF-kappaB, promoting the expression of both TGF-beta1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.
Product Categories/Family for Indoxyl sulfate potassium salt, inhibitor
References
1. Zgoda-Pols J R, Chowdhury S, Wirth M, et al. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists[J]. Toxicology & Applied Pharmacology, 2011, 255 (1):48-56.
2. Ito S, Osaka M, Edamatsu T, et al. Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation.[J]. Journal of Atherosclerosis & Thrombosis, 2016, 23 (8):iii510-iii511.
2. Ito S, Osaka M, Edamatsu T, et al. Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation.[J]. Journal of Atherosclerosis & Thrombosis, 2016, 23 (8):iii510-iii511.
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Product Notes
The Indoxyl sulfate potassium salt (Catalog #AAA5751408) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Indoxyl sulfate potassium salt, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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