HIV-1 inhibitor 5b, Inhibitor
HIV-1 inhibitor 5b
Purity
>98% (HPLC)
Synonyms
HIV-1 inhibitor 5b; inhibitor
Purity/Purification
>98% (HPLC)
Target
HIV
Receptor
HIV
Chemical Name
1-(5-amino-2, 4-difluorophenyl)-7-(3, 5-dimethyl-4, 5-dihydroisoxazol-4-yl)quinolin-4(1H)-one
Molecular Formula
C20H17F2N3O2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for HIV-1 inhibitor 5b, inhibitor
HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1nM without significant cytotoxicity (CC50>20uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3nM); shows a chemical backbone similar to the clinically used integrase (IN) strand transfer inhibitor (INSTI) elvitegravir, but has no detectable INSTI activity; various drug-resistant HIV-1 strains did not display cross resistance to HIV-1 inhibitor 5b; remains its anti-HIV-1 activity even after the viral integration stage, significantly suppresses p24 antigen production in HIV-1 latently infected cells exposed with TNF-alpha; demonstrates favorable pharmacokinetic profiles in mice.
Product Categories/Family for HIV-1 inhibitor 5b, inhibitor
References
1. Shiroishi-Wakatsuki T, et al. Antiviral Res. 2019 Feb; 162:101-109.
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Product Notes
The HIV-1 inhibitor 5b (Catalog #AAA3607086) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HIV-1 inhibitor 5b, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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