Structure
GSK 356278, Inhibitor
GSK 356278
Purity
>98% (HPLC)
Synonyms
GSK 356278; GSK356278; GSK-356278; inhibitor
Purity/Purification
>98% (HPLC)
Target
PDE
Receptor
PDE
Chemical Name
5-(5-((2, 4-dimethylthiazol-5-yl)methyl)-1, 3, 4-oxadiazol-2-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3, 4-b]pyridin-4-amine
SMILES
CCN1N=CC2=C(NC3CCOCC3)C(C4=NN=C(CC5=C(C)N=C(C)S5)O4)=CN=C21
Molecular Formula
C21H25N7O2S
CAS Number
720704-34-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK 356278, inhibitor
A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B); equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7, exhibits >100-fold selectivity for PDE4B over the other 10 PDEs; inhibits LPS-induced release of TNF-alpha in human whole blood with pIC50 of 7.6, demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in models of anxiety. Anxiety Phase 1 Clinical
Product Categories/Family for GSK 356278, inhibitor
References
1. Rutter AR, et al. J Pharmacol Exp Ther. 2014 Jul; 350 (1):153-63.
2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.
2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.
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Product Notes
The GSK 356278 (Catalog #AAA3605755) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK 356278, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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