Erlotinib, Inhibitor

Erlotinib

Cat. Num. AAA384548

• Purity: >98%
• Synonyms: Erlotinib; CP-358; 774; CP-358774; CP358774; OSI-774; OSI 774; OSI774; Erlotinib free base.; inhibitor

• Purity/Purification: >98%
• Concentration: 0.1 mM: 25.42 mL (1 mg); 127.08 mL (5 mg); 254.17mL (10 mg); 0.5 mM: 5.08 mL (1 mg); 25.42 mL (5 mg); 50.83 mL (10 mg); 1 mM: 2.54 mL (1 mg); 12.71 mL (5 mg); 25.42 mL (10 mg); 5 mM: 0.51 mL (1 mg); 2.54 mL (5 mg); 5.08 mL (10 mg) (varies by lot)

• CAS Number: 183321-74-6
• Formula: C22H23N3O4?
• SMILES: COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC
• Actions: Inhibitor
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 2 years

Chemical Structure

Related Product Information for Erlotinib, inhibitor

Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.

References

Manabe A, .et al. Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells, J Cell Physiol, 2018, Nov 21 PMID: 30461012
Yui Takashina, .et al. Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells, Nutrients, 2018, Oct; 10(10): 1345 PMID: 30241394
Furukawa C, .et al. Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, J Cell Physiol, 2017, Oct;232(10):2841-2850 PMID: 27925186
Xiaoyu Yang, .et al. Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs, Free Radic Biol Med, 2016, Aug; 97: 342-350 PMID: 27368132