Chemical Structure
Dynasore, Inhibitor
Dynasore
Purity
>98%
Synonyms
Dynasore; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 31.03 mL (1 mg); 155.13 mL (5 mg); 310.25mL (10 mg)
0.5 mM: 6.21 mL (1 mg); 31.03 mL (5 mg); 62.05 mL (10 mg)
1 mM: 3.1 mL (1 mg); 15.51 mL (5 mg); 31.03 mL (10 mg)
5 mM: 0.62 mL (1 mg); 3.1 mL (5 mg); 6.21 mL (10 mg) (varies by lot)
0.5 mM: 6.21 mL (1 mg); 31.03 mL (5 mg); 62.05 mL (10 mg)
1 mM: 3.1 mL (1 mg); 15.51 mL (5 mg); 31.03 mL (10 mg)
5 mM: 0.62 mL (1 mg); 3.1 mL (5 mg); 6.21 mL (10 mg) (varies by lot)
CAS Number
304448-55-3
Formula
C18H14N2O4
SMILES
C1=CC=C2C=C(C(=CC2=C1)C(=O)NN/C=C/3\C=CC(=O)C(=C3)O)O
Actions
Inhibitor
Solubility (DMSO)
64 mg/mL (198.56 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for Dynasore, inhibitor
Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity.
References
Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKÎu-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 PMID: 27733684
Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 PMID: 27733684
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Product Notes
The Dynasore (Catalog #AAA385393) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dynasore, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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