Chemical Structure
Demethyleneberberine, Inhibitor
Demethyleneberberine
Purity
98.00%
Synonyms
Demethyleneberberine; P450; HIF; NOS; inhibitor
Purity/Purification
98.00%
Form/Format
POWDER
CAS Number
25459-91-0
Formula
C19H18NO4+
Smiles
Oc1cc2c3cc4ccc(OC)c(OC)c4c[n+]3CCc2cc1O
Solubility
DMSO: Soluble
Pathways
Metabolism; Angiogenesis; Immunology; Inflammation
Receptor
CYP17; HIF; NOS
Product Remark
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
Powder: 3 years -20 degree C
In Solvent: 2 years -80 degree C
In Solvent: 2 years -80 degree C
Chemical Structure
Chemical Structure
Related Product Information for Demethyleneberberine, inhibitor
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor alpha, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-gamma coactivator-1alpha pathway-associated fatty acid oxidation in chronic ethanol-fed mice.
References
1. Zhang P1,et al.Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.J Pharmacol Exp Ther. 2015 Jan; 352(1):139-47.
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Product Notes
The Demethyleneberberine (Catalog #AAA5750802) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Demethyleneberberine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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