Structure
Cyclopamine tartrate, Inhibitor
Cyclopamine tartrate
Purity
>98% (HPLC)
Synonyms
Cyclopamine tartrate; inhibitor
Purity/Purification
>98% (HPLC)
Target
Hedgehog (Hh)
Receptor
Hedgehog (Hh)
Chemical Name
(3S, 3'R, 3a'S, 6aS, 6bS, 6'S, 7a'R, 9R, 11aS, 11bR)-3', 6', 10, 11b-tetramethyl-1, 2, 3, 3a', 4, 4', 5', 6, 6a, 6b, 6', 7, 7', 7a', 8, 11, 11a, 11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9, 2'-furo[3, 2-b]pyridin]-3-ol(2R, 3R)-2, 3-dihydroxysuccinate
Molecular Formula
C58H88N2O10
CAS Number
1178510-81-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Cyclopamine tartrate, inhibitor
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Product Categories/Family for Cyclopamine tartrate, inhibitor
References
1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15; 19 (2):328-31.
2. Cooper MK, et al. Science. 1998 Jun 5; 280 (5369):1603-7.
3. Incardona JP, et al. Development. 1998 Sep; 125 (18):3553-62.
2. Cooper MK, et al. Science. 1998 Jun 5; 280 (5369):1603-7.
3. Incardona JP, et al. Development. 1998 Sep; 125 (18):3553-62.
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Product Notes
The Cyclopamine tartrate (Catalog #AAA3600605) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cyclopamine tartrate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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