Cycloheterophyllin, Inhibitor

Cycloheterophyllin

Purity

98.00%

Synonyms

Cycloheterophyllin; inhibitor

Ordering
Cat. Num. AAA5760275 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H30O7

SMILES

C\C(C)=C/Cc1c2OC(C)(C)C=Cc2c(O)c2c1oc1-c3cc(O)c(O)cc3OC(\C=C(/C)C)c1c2=O

CAS Number

36545-53-6

Target & IC50

PKA
PKC
NADPH-oxidase

In Vitro

Extending the aforementioned investigations, in this study, human dermal fibroblasts were used to investigate the protective effect of Cycloheterophyllin against UV-induced damage. We found that Cycloheterophyllin not only significantly increased cell viability, but also attenuated the phosphorylation of MAPK after UVA exposure. Furthermore, Cycloheterophyllin could reduce hydrogen peroxide (H2O2) generation and down-regulate H2O2-induced MAPK phosphorylation. In the in vivo studies, the topical application of Cycloheterophyllin before UVA irradiation significantly decreased trans-epidermal water loss (TEWL), erythema, and blood flow rate[1]

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Related Product Information for Cycloheterophyllin, inhibitor

Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.

Product Categories/Family for Cycloheterophyllin, inhibitor

GPCR/G Protein; PKA; Protein Tyrosine Kinase/RTK; Cytoskeletal Signaling; Immunology/Inflammation

References

Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.PLoS One. 2016 Sep 1;11(9):e0161767.
Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.PLoS One. 2016 Sep 1;11(9):e0161767.
Novel antiplatelet constituents from formosan moraceous plants.J Nat Prod. 1996 Sep;59(9):834-8.

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Product Notes

The Cycloheterophyllin (Catalog #AAA5760275) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cycloheterophyllin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Cycloheterophyllin, Inhibitor