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Chemical Structure

CK-1827452 (Omecamtiv mecarbil), Inhibitor

CK-1827452 (Omecamtiv mecarbil)

Purity
>98%
Synonyms
CK-1827452 (Omecamtiv mecarbil); CK1827452; Omecamtiv Mecarbil; inhibitor
Ordering
For Research Use Only!
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 24.91 mL (1 mg); 124.55 mL (5 mg); 249.11mL (10 mg)
0.5 mM: 4.98 mL (1 mg); 24.91 mL (5 mg); 49.82 mL (10 mg)
1 mM: 2.49 mL (1 mg); 12.46 mL (5 mg); 24.91 mL (10 mg)
5 mM: 0.5 mL (1 mg); 2.49 mL (5 mg); 4.98 mL (10 mg) (varies by lot)
CAS Number
873697-71-3
Formula
C20H24FN5O3
SMILES
CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
Actions
Activator
In Vivo Solvent
1% DMSO/30% polyethylene glycol/1% Tween 80
Solubility (DMSO)
80 mg/mL (199.28 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder

Chemical Structure

Chemical Structure
Related Product Information for CK-1827452 (Omecamtiv mecarbil), inhibitor
CK-1827452 is a selective cardiac specific myosin activator.
References
Thinh T. Kieu, .et al. Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature, Biophysical Journal, 2019, 2019
Alexandre J. S. Ribeiro, .et al. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes, Circ Res, 2017, May 12; 120(10): 1572-1583 PMID: 28400398
Anja M. Swenson, .et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle, J Biol Chem, 2017, Mar 3; 292(9): 3768-3778 PMID: 28082673
Nánási P Jr, .et al. Omecamtiv mecarbil activates ryanodine receptors from canine cardiac but not skeletal muscle, Eur J Pharmacol, 2017, Aug 15;809:73-79 PMID: 28506910
Horv??th B, .et al. Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes, Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 PMID: 28940010
Szentandrassy N, .et al. Dose-dependent electrophysiological effects of the myosin activator omecamtiv mecarbil in canine ventricular cardiomyocytes, J Physiol Pharmacol, 2016, Aug;67(4):483-489 PMID: 27779469
L Nagy, .et al. The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat, Br J Pharmacol, 2015, Sep; 172(18): 4506-4518 PMID: 26140433
Larissa Butler, .et al. Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment., Toxicol Sci, 2015, Jun;145(2):396-406 PMID: 25820236

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Product Notes

The CK-1827452 (Omecamtiv mecarbil) (Catalog #AAA384518) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CK-1827452 (Omecamtiv mecarbil), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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