Cidofovir dihydrate, Inhibitor
Cidofovir dihydrate
Purity
99.97%
Synonyms
Cidofovir dihydrate; (S)-HPMPC; HPMPC; GS 0504; inhibitor
Purity/Purification
99.97%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C8H14N3O6P
SMILES
O.O.Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
CAS Number
149394-66-1
Kinase Assay
EGFR kinase assays: In vitro inhibitory enzyme kinetic assays using recombinant EGFR L858R/T790M and WT protein and are performed using the ATP/NADH coupled assay system in a 96-well format. WZ4002 is added to determine its inhibitory effects.
In Vitro
Cidofovir (5mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Cidofovir dihydrate, inhibitor
Cidofovir is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. idofovir is an injectable antiviral medication primarily used as a treatment, for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS
Product Categories/Family for Cidofovir dihydrate, inhibitor
References
Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.
Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.
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Product Notes
The Cidofovir dihydrate (Catalog #AAA5759505) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cidofovir dihydrate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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