Caspase 1, Inhibitor | Casp1, inhibitor
Caspase 1 (ICE-Family) Inhibitor, Cell Culture, 2mM, (YVAD-FMK)
98% (HPLC)
98% (HPLC)
Dilution: 1ul/1-5ml of culture medium (1000X-5000X) for inhibiting Caspase-1 activity in Jurkat cell culture. The optimal dilution may vary for different cells and culture conditions.
NCBI and Uniprot Product Information
NCBI Description
apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006]
Uniprot Description
Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis
By similarity.
Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed bya 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18
By similarity.
Subcellular location: Cytoplasm.
Post-translational modification: The two subunits are derived from the precursor sequence by a autocatalytic mechanism.
Sequence similarities: Belongs to the peptidase C14A family.Contains 1 CARD domain.
Research Articles on Casp1
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Product Notes
The Casp1 casp1 (Catalog #AAA655446) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. Suitable for use as an inhbitor of Caspase 1 activity in Jurkat cell cultures. Dilution: 1ul/1-5ml of culture medium (1000X-5000X) for inhibiting Caspase-1 activity in Jurkat cell culture. The optimal dilution may vary for different cells and culture conditions. Researchers should empirically determine the suitability of the Casp1 casp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caspase 1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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