Structure
Bemesetron, Inhibitor
Bemesetron
Purity
98.00%
Synonyms
Bemesetron; MDL 72222; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 2mg/mL (6.37mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H17Cl2NO2
SMILES
O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=CC(Cl)=C3
CAS Number
40796-97-2
Target & IC50
5-HT3 Receptor: ic50 0.33nM
In Vitro
Bemesetron (0.1, 1 and 10mg/kg; i.p.) is used in male adult albino mice. The lowest dose do not cause any significant change in catalepsy. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3]. Bemesetron (1mg/kg) causes a significant reduction of catalepsy (from 90 min after Haloperidol), while 10mg/kg significantly potentiates the phenomenon (from 60 min after Haloperidol).
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for Bemesetron, inhibitor
Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50:nM). It has Neuroprotective effect[2].
Product Categories/Family for Bemesetron, inhibitor
References
Peters JA, et al. An electrophysiological investigation of the properties of 5-HT
Peters JA, et al. An electrophysiological investigation of the properties of 5-HT
Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.
Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.
Silva SR, et al. Effects of 5-HT
Silva SR, et al. Effects of 5-HT
Peters JA, et al. An electrophysiological investigation of the properties of 5-HT
Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.
Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300.
Silva SR, et al. Effects of 5-HT
Silva SR, et al. Effects of 5-HT
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Product Notes
The Bemesetron (Catalog #AAA5754592) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bemesetron, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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