Structure
BAY 61-3606 dihydrochloride, Inhibitor
BAY 61-3606 dihydrochloride
Purity
>98% (HPLC)
Synonyms
BAY 61-3606 dihydrochloride; BAY61-3606 dihydrochloride; BAY 61-3606; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=4.6mg/mL
Target
Syk
Receptor
Syk
Chemical Name
3-Pyridinecarboxamide, 2-[[7-(3, 4-dimethoxyphenyl)imidazo[1, 2-c]pyrimidin-5-yl]amino]-, hydrochloride(1:2)
SMILES
COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl
Molecular Formula
C20H20Cl2N6O3
CAS Number
648903-57-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 61-3606 dihydrochloride, inhibitor
A potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src; inhibits not only degranulation (IC50=5-46nM) but also lipid mediator and cytokine synthesis in mast cells; suppresses B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes; suppresses antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema at 3mg/kg in rats; orally bioavailable. Allergy Preclinical
Product Categories/Family for BAY 61-3606 dihydrochloride, inhibitor
References
1. Yamamoto N, et al. J Pharmacol Exp Ther. 2003 Sep; 306 (3):1174-81.
2. Tabeling C, et al. Allergy. 2017 Jul; 72 (7):1061-1072.
3. Perova T, et al. Sci Transl Med. 2014 May 14; 6 (236):236ra62.
2. Tabeling C, et al. Allergy. 2017 Jul; 72 (7):1061-1072.
3. Perova T, et al. Sci Transl Med. 2014 May 14; 6 (236):236ra62.
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Product Notes
The BAY 61-3606 dihydrochloride (Catalog #AAA3605461) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 61-3606 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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