BAY-1436032, inhibitor
BAY-1436032
Purity
98.00%
Synonyms
BAY-1436032; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 120mg/mL (245.14mM) Need ultrasonic and warming
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Water: Insoluble
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H29F3N3O3
SMILES
O=C(O)CCC1=CC=C2C(N=C(NC3=CC=C(OC(F)(F)F)C=C3)N2[C@]4CC(C)(C)C[C@@H](C)C4)=C1
CAS Number
1803274-65-8
Cell Research
Colony-forming cell (CFC) units are assayed in methylcellulose supplemented with 10ng/mL IL-3, 10ng/mL GM-CSF, 50ng/mL SCF, 50ng/mL FLT3-ligand and 3U/mL EPO. Vehicle or BAY-1436032 is added to methylcellulose containing 1 x 10^5 human mononuclear cells, which are plated in duplicate. Colonies are evaluated microscopically 10 to 14 days after plating by standard criteria.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for BAY-1436032, inhibitor
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
Product Categories/Family for BAY-1436032, inhibitor
References
Chaturvedi A, et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. Leukemia. 2017 Oct;31(10):2020-2028.
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Product Notes
The BAY-1436032 (Catalog #AAA5764300) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY-1436032, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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