AT-406 (SM-406, ARRY-334543), Inhibitor

AT-406 (SM-406, ARRY-334543)

Cat. Num. AAA384249

• Purity: >98%
• Synonyms: AT-406 (SM-406; ARRY-334543); AT406; SM-406; ARRY-334543; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 17.8 mL (1 mg); 89.01 mL (5 mg); 178.03mL (10 mg); 0.5 mM: 3.56 mL (1 mg); 17.8 mL (5 mg); 35.61 mL (10 mg); 1 mM: 1.78 mL (1 mg); 8.9 mL (5 mg); 17.8 mL (10 mg); 5 mM: 0.36 mL (1 mg); 1.78 mL (5 mg); 3.56 mL (10 mg) (varies by lot)

• CAS Number: 1071992-99-8
• Formula: C32H43N5O4
• SMILES: C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
• Actions: Inhibitor
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for AT-406 (SM-406, ARRY-334543), inhibitor

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

References

Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104