Structure
ASP7657, Inhibitor
ASP7657
Purity
>98% (HPLC)
Synonyms
ASP7657; ASP 7657; ASP-7657; inhibitor
Purity/Purification
>98% (HPLC)
Target
Prostaglandin Receptor
Receptor
Prostaglandin Receptor
Chemical Name
(1r, 4r)-4-((1-(quinolin-2-ylmethyl)-5-(trifluoromethyl)-1H-indole-7-carboxamido)methyl)cyclohexane-1-carboxylic acid
SMILES
FC(F)(F)C1=CC2=CC[N](CC(C=C3)=NC4=C3C=CC=C4)=C2C(C([N]C[C@@H]5CC[C@@H](C([O])=O)CC5)=O)=C1
Molecular Formula
C28H26F3N3O3
CAS Number
1196045-28-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ASP7657, inhibitor
ASP7657 (ASP-7657) is a potent, selective, orally active prostaglandin EP4 receptor antagonist with Ki values of 6.02nM and 2.21nM for rat and human EP4 receptors, resepctively; potently inhibits the PGE2-induced cAMP increase in CHO cells expressing rat EP4 receptors and human lymphoblastoid T (Jurkat) cells, with IC50 values of 0.86nM and 0.29nM, respectively; does not inhibit the PGE2-induced intracellular calcium increase in HEK293 cells expressing rat EP1 and EP3 receptors, or cAMP increase in CHO cells expressing rat EP2 receptors; dose-dependently inhibits the PGE2-mediated inhibition of LPS-induced TNF-alpha release from rat whole blood culture, attenuates albuminuria in type 2 diabetic mice at dose of 0.1mg/kg. Diabetes Phase 1 Discontinued
Product Categories/Family for ASP7657, inhibitor
References
1. Mizukami K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug 3. doi: 10.1007/s00210-018-1545-x.
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Product Notes
The ASP7657 (Catalog #AAA3600689) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ASP7657, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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