Structure
AS602868, Inhibitor
AS602868
Purity
>98% (HPLC)
Synonyms
AS602868; AS 602868; SPC 839; inhibitor
Purity/Purification
>98% (HPLC)
Target
IkappaB kinase (IKK)
Receptor
IkappaB kinase (IKK)
Chemical Name
1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)-3-methyl-pyrrole-2, 5-dione
SMILES
O=C(C(C)=C1)N(NC2=C3C(OC)=CC=CC3=NC(C4=CC=CS4)=N2)C1=O
Molecular Formula
C18H14N4O3S
CAS Number
219773-55-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AS602868, inhibitor
A potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60nM and Ki of 20nM, also interfers directly with FLT3 kinase activation; displays no significant inhibitory activity for IKK1 and a large panel of recombinant kinases; prevents TNF-alpha induction of the antiapoptotic genes coding for c-IAP-2, Bclx, Bfl-1/A1 and Traf-1, induces cell death in Jurkat leukemic T cells. Blood Cancer Phase 1 Discontinued
Product Categories/Family for AS602868, inhibitor
References
1. Frelin C, et al. Oncogene. 2003 Nov 6; 22 (50):8187-94.
2. Frelin C, et al. Blood. 2005 Jan 15; 105 (2):804-11.
3. Griessinger E, et al. Leukemia. 2007 May; 21 (5):877-85.
4. Jourdan M, et al. Br J Haematol. 2007 Jul; 138 (2):160-8.
2. Frelin C, et al. Blood. 2005 Jan 15; 105 (2):804-11.
3. Griessinger E, et al. Leukemia. 2007 May; 21 (5):877-85.
4. Jourdan M, et al. Br J Haematol. 2007 Jul; 138 (2):160-8.
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Product Notes
The AS602868 (Catalog #AAA3603504) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AS602868, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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