Apalutamide (ARN-509), Inhibitor

Apalutamide (ARN-509)

Cat. Num. AAA384224

• Purity: >98%
• Synonyms: Apalutamide (ARN-509); ARN509; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 20.95 mL (1 mg); 104.73 mL (5 mg); 209.47mL (10 mg); 0.5 mM: 4.19 mL (1 mg); 20.95 mL (5 mg); 41.89 mL (10 mg); 1 mM: 2.09 mL (1 mg); 10.47 mL (5 mg); 20.95 mL (10 mg); 5 mM: 0.42 mL (1 mg); 2.09 mL (5 mg); 4.19 mL (10 mg) (varies by lot)

• CAS Number: 956104-40-8
• Formula: C21H15F4N5O2S
• SMILES: CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F
• Actions: Inhibitor
• In Vivo Solvent: 0.5% CMC, pH4.0
• Solubility (DMSO): 18 mg/mL (37.7 mM)
• Solubility (Ethanol): 5 mg/mL (10.47 mM)
• Solubility (in vivo): 14 mg/mL
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for Apalutamide (ARN-509), inhibitor

ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.

References

Frédérique Mittler, .et al. High-Content Monitoring of Drug Effects in a 3D Spheroid Model, Front Oncol, 2017, 7: 293 PMID: 29322028