Structure
AGI-1067, Inhibitor
AGI-1067
Purity
>98% (HPLC)
Synonyms
AGI-1067; Succinobucol; AGI 1067; AGI1067; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: Soluble (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Other Targets
Receptor
Others
Chemical Name
4-(4-((1-((3, 5-bis(1, 1-Dimethylethyl)-4-hydroxyphenyl)sulfanyl)-1-methylethyl)sulfanyl)-2, 6-bis(1, 1-dimethylethyl)phenoxy)-4-oxobutanoic acid
SMILES
O=C(O)CCC(OC1=C(C(C)(C)C)C=C(SC(C)(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C)C=C1C(C)(C)C)=O
Molecular Formula
C35H52O5S2
CAS Number
216167-82-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AGI-1067, inhibitor
AGI-1067 (Succinobucol) is a potent inhibitor of TNF-alpha-inducible expression of VCAM-1, MCP-1 and E-selectin (IC50=6, 10 and 25uM) with concurrent antioxidant and lipid-modulating properties; inhibits atherosclerosis in LDL receptor-deficient and apolipoprotein E-deficient mice, also reduces VCAM-1 and MCP-1 mRNA levels in lungs of LPS-stimulated mice; inhibits atherosclerosis not only via its lipid-lowering effects but also by having direct anti-inflammatory effects on the vessel wall. Diabetes Phase 3 Clinical
Product Categories/Family for AGI-1067, inhibitor
References
1. Sundell CL, et al. J Pharmacol Exp Ther. 2003 Jun; 305 (3):1116-23.
2. Meng CQ, et al. Bioorg Med Chem Lett. 2002 Sep 16; 12 (18):2545-8.
3. Tardif JC, et al. Circulation. 2003 Feb 4; 107 (4):552-8.
4. Kunsch C, et al. J Pharmacol Exp Ther. 2004 Mar; 308 (3):820-9.
2. Meng CQ, et al. Bioorg Med Chem Lett. 2002 Sep 16; 12 (18):2545-8.
3. Tardif JC, et al. Circulation. 2003 Feb 4; 107 (4):552-8.
4. Kunsch C, et al. J Pharmacol Exp Ther. 2004 Mar; 308 (3):820-9.
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Product Notes
The AGI-1067 (Catalog #AAA3603448) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AGI-1067, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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