Aaptamine, Inhibitor
Aaptamine
Purity
98.00%
Synonyms
Aaptamine; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C13H12N2O2
SMILES
COc1cc2ccnc(C=CN3)c2c3c1OC
CAS Number
85547-22-4
Target & IC50
p53
TNF-alpha
c-Myc
TNF-alpha
c-Myc
In Vitro
All Aaptamines were found to be equally effective in both cell lines, excluding cross-resistance between Aaptamines and cisplatIn vitro. At the inhibitory concentration (IC50), Aaptamine exerted an antiproliferative effect, whereas demethyloxyAaptamine and isoAaptamine were strong inducers of apoptosis. We analyzed the changes in the proteome of NT2-R cells treated with these compounds. 16-22 proteins were found to be significantly altered, of which several were validated by Western blotting and two-dimensional Western blotting analysis. Changes in the proteome pattern frequently resulted from post-transcriptional protein modifications, i.e. phosphorylation or hypusination in the case of eIF5A. Although the lists of altered proteins were heterogeneous and compound-specific, gene ontology analyses identified rather similar profiles regarding the affected molecular functions. Ingenuity pathway analysis by IPA put the following factors in a central position of the hypothetical networks: myc and p53 for Aaptamine; tumor necrosis factor (TNF) for demethyloxyAaptamine; and all three, myc, p53, and TNF for isoAaptamine[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Aaptamine, inhibitor
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
Product Categories/Family for Aaptamine, inhibitor
References
Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.J Proteomics. 2014 Jan 16;96:223-39.
Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.J Proteomics. 2014 Jan 16;96:223-39.
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.J Pharm Pharmacol. 1984 Nov;36(11):785-6.
Anti-photoaging effect of aaptamine in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes.J Asian Nat Prod Res. 2014 Dec;16(12):1139-47.
Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.J Proteomics. 2014 Jan 16;96:223-39.
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.J Pharm Pharmacol. 1984 Nov;36(11):785-6.
Anti-photoaging effect of aaptamine in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes.J Asian Nat Prod Res. 2014 Dec;16(12):1139-47.
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Product Notes
The Aaptamine (Catalog #AAA5760099) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Aaptamine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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