Structure
AA92593, inhibitor
AA92593
Purity
98.00%
Synonyms
AA92593; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C13H19NO3S
SMILES
COc1ccc(cc1C)[S](=O)(=O)N2CCCCC2
CAS Number
457961-34-1
Target & IC50
melanopsin
In Vitro
The involvement of melanopsin in the regulation of melatonin was also determined by using a specific inhibitor AA92593 and by inhibiting melanopsin-induced phospholipase C activation. Under this situation neither AANAT nor melatonin levels changed under light conditions (n = 4, ***p <0.001). The discovery of melanopsin in the lens opens the possibility of regulating melatonin synthesis with the corresponding implication as an antioxidant substance[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for AA92593, inhibitor
AA92593 has been used as a selective inhibitor of melanopsin.
References
Alkozi H A, Wang X, Jesus P D L M, et al. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis[J]. Experimental Eye Research, 2016:168.
Alkozi H A, Wang X, Jesus P D L M, et al. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis[J]. Experimental Eye Research, 2016:168.
Hehr, Carrie, L, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of -MSH in the pituitary gland[J]. Pigment cell & melanoma research, 2015.
Hehr, Carrie, L, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of -MSH in the pituitary gland[J]. Pigment cell & melanoma research, 2015.
Alkozi H A, Wang X, Jesus P D L M, et al. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis[J]. Experimental Eye Research, 2016:168.
Hehr, Carrie, L, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of -MSH in the pituitary gland[J]. Pigment cell & melanoma research, 2015.
Hehr, Carrie, L, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of -MSH in the pituitary gland[J]. Pigment cell & melanoma research, 2015.
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Product Notes
The AA92593 (Catalog #AAA5759352) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AA92593, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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