Structure

3-arylisoquinolinamine derivative, Inhibitor

3-arylisoquinolinamine derivative

Purity

98.00%

Synonyms

3-arylisoquinolinamine derivative; inhibitor

Ordering
Cat. Num. AAA5752614 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

DMSO: 50mg/mL (170.44mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H19N3O

SMILES

NC1=NC(C2=CC=CC(OC)=C2)=CC(C=C3)=C1C=C3N(C)C

CAS Number

1029008-71-6

Target & IC50

breast MDA-MB-231: ic50 21nM
pancreas PANC-1: ic50 19nM
colon HCT 116: ic50 17nM
prostate PC3: ic50 19nM
ovary OVCAR-3: ic50 14nM
melanoma SK-MEL-28: ic50 32nM
kidney Caki-1: ic50 22nM
glioblastoma SNB19: ic50 32nM

In Vitro

3-arylisoquinolinamine derivative has higher antitumor efficacy (69.2% inhibition) than that of the control drug, Paclitaxel (48.8% inhibition) in the inhibition of growth of tumor in an animal model [2].

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Related Product Information for 3-arylisoquinolinamine derivative, inhibitor

3-arylisoquinolinamine derivative is a compound with antitumor activity.

References

Yang SH, et al. Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5277-81.
Yang SH, et al. Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5277-81.
Young Bok Lee, et al. 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents. WO 2008063548 A2.
Young Bok Lee, et al. 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents. WO 2008063548 A2.

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Product Notes

The 3-arylisoquinolinamine derivative (Catalog #AAA5752614) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "3-arylisoquinolinamine derivative, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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3-arylisoquinolinamine derivative, Inhibitor